GREENFIELD, Ind. (Sept. 8, 2025) – Elanco Animal Health Incorporated (NYSE: ELAN) has announced significant advancements with its two most recent pet health innovations — Credelio Quattro and Zenrelia — further demonstrating the company’s commitment to helping pet owners and veterinarians around the world go beyond today’s standard of treatment.

Credelio Quattro, Elanco’s latest parasite innovation brought to market, became Elanco’s fastest pet health blockbuster in history and one of the industry’s fastest ever, especially with a single geographic approval, reaching blockbuster status of $100 million in net sales in less than eight months. Credelio Quattro offers the broadestⁱ parasite protection available in an isoxazoline endectocide covering six types of parasites — fleas, ticks, heartworm disease, and three risky intestinal parasites — roundworms, hookworms, and tapeworms.

“Credelio Quattro continues to break boundaries when it comes to offering veterinarians and pet owners parasite protection,” said Bobby Modi, Executive Vice President, U.S. Pet Health and Global Digital Transformation at Elanco. “We’re seeing incredibly strong demand for all-in-one products from pet owners and veterinarians alike. In fact, Credelio Quattro captured approximately 14% of the dollar share in broad-spectrum sales out of U.S. veterinary clinics in June. The introduction of Credelio Quattro has bolstered our broader Elanco portfolio in U.S. veterinary clinics, with Elanco now offering veterinarians a complete ecto, endo, and endecto portfolio with a variety of parasite coverage at a variety of price points to meet veterinarian and pet owner needs.”

Human and pet cases of tickborne disease, such as Lyme disease which is spread by the black-legged tick, are on the rise. According to the Companion Animal Parasite Council (CAPC), black-legged ticks are found across much of the eastern half of the United States, with aggressive populations in the North that appear to pose a higher risk of transmitting Lyme disease to humans and dogs; and these populations are also spreading South and West in the United States, as well as northward into new areas of Canada. Multiple studies have shown that areas of high risk for dogs are the same areas that humans are most likely to test positive for Lyme disease as well. CAPC recommends using products on pets that repel or quickly kill ticks before pathogens are transmitted. Credelio Quattro (lotilaner, moxidectin, praziquantel, and pyrantel chewable tablets) also contains lotilaner that kills ticksⁱⁱ fasterⁱⁱⁱ than sarolaner in Simparica Trio^® and afoxolaner in NexGard^®, protecting dogs against pathogen-carrying ticks.

“When I talk to veterinarians and pet owners, I hear they want something that’s reliable, that’s going to be easy to give and that’s powerful against the different parasites: heartworms, ticks, and intestinal parasites including hookworms and tapeworms,” said Dr. Lindsay Starkey, veterinarian and tenured Associate Professor of Parasitology at Oklahoma State University’s College of Veterinary Medicine. “Credelio Quattro meets all of these expectations with its broad spectrum parasite control.”

Credelio Quattro joins Experior® as Elanco’s second of six recently launched blockbuster-potential products to reach the blockbuster milestone of $100 million annual net sales. Elanco continues to prepare to take Credelio Quattro global, with numerous submissions made in Australia, Canada, the EU, the UK, and Japan, setting up the company’s expected geographic expansion for the product starting in 2026.

Zenrelia Now in Market in EU and Great Britain

Zenrelia, an effective, convenient, and safe once-daily oral JAK inhibitor, continues its launch progress globally, gaining approval from the United Kingdom’s Veterinary Medicines Directorate in August. Additionally, launch progress continues across the EU and Great Britain with product supply now in market for veterinarians and pet owners.

“Now we have a medication that is once a day right from the start. I think it will really help improve that owner, patient, pet bond, it will hopefully help reduce caregiver burden and will improve patient and carer quality of life as well,” said Dr. Victoria Robinson BVM&S, BSc, CertAVP (VD), DipECVD, MRCVS, RCVS and European Specialist in Veterinary Dermatology. “Knowing what I currently know about Zenrelia, I am keen to use it in the clinic and start prescribing it.”

This launch represents a pivotal milestone within the international canine dermatology market, offering a single daily dose for controlling pruritus (itching) associated with allergic dermatitis and atopic dermatitis in dogs over 12 months of age. Zenrelia is now available in the European Union, Great Britain, Brazil, Canada, Japan, and the United States. The Zenrelia EU label is consistent with other markets outside North America where the product has already been approved.

“Zenrelia joins our exciting, growing international pet health portfolio, including AdTab, Credelio Plus, Galliprant (grapiprant tablets) and others,” said Ramiro Cabral, Executive Vice President, Elanco International. “We are very pleased with the results we are seeing in the global market, with more than half a million dogs treated with Zenrelia.”

As part of the EU approval process, Elanco conducted a head-to-head non-inferiority study versus the marketplace incumbent, Apoquel. The randomized, double-blind study of 338 client-owned dogs with confirmed atopic dermatitis was conducted across 25 study sites in four countries. The study is published in a leading peer-reviewed, international journal, Veterinary Dermatology: https://doi.org/10.1111/vde.13319.